Chromomycin A 3 , an antitumor antibiotic: tissue distribution studies in mice as measured by microbial assay.
نویسندگان
چکیده
A microbiological assay has been developed for chromomycin A(3), an antitumor antibiotic showing promise in human trials. The assay bacterium is a derived strain of Streptococcus faecalis resistant to methotrexate. Studies with mice revealed that relatively high concentrations of this antibiotic were maintained in the blood, kidneys, and liver of mice after a single-dose intraperitoneal injection of the drug.
منابع مشابه
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ورودعنوان ژورنال:
- Applied microbiology
دوره 22 3 شماره
صفحات -
تاریخ انتشار 1971